Titanium-catalyzed Reformatsky-type reaction

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• 作者：Laura Sgreccia ; Marco B ; ini ; Stefano Morganti ; Arianna Quintavalla ; Achille Umani-Ronchi ; Pier Giorgio Cozzi
• 关键词：Reformatsky reaction ; Titanium ; Mn ; Catalysis
• 刊名：Journal of Organometallic Chemistry
• 出版年：2007
• 出版时间：1 July 2007
• 年：2007
• 卷：692
• 期：15
• 页码：3191-3197
• 全文大小：173 K

文摘

A catalytic titanium mediated Reformatsky reaction is presented. The technique employs cyclopentadienyltitaniumdichloride(IV) (10 mol % ) in conjunction with Mn (2 equiv.), as the stoichiometric reductant, and (CF₃CO)₂O (1.5 equiv.), as the scavenger, and it is based on the formation of titanocene(III) chloride as a mild and homogeneous single-electron reductant. The reaction gives moderate yields of the desired Reformatsky adduct, and it works well with aromatic and aliphatic aldehydes.