A Facile Synthesis of Cephem Side Chains by Palladium Catalyzed Cross-Coupling of 3-Substituted-Δ³-Cephems with Dialkylzinc or Vinyltributyltin

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• 作者：Contento ; Michele ; Da Col ; Marco ; Galletti ; Paola ; Sandri ; Sergio ; Umani-Ronchi ; Achille
• 刊名：Tetrahedron Letters
• 出版年：1998
• 出版时间：November 19, 1998
• 年：1998
• 卷：39
• 期：47
• 页码：8743-8746
• 全文大小：196 K

文摘

Synthesis of 3-vinyl- and 3-alkyl-Δ³-cephems was performed in a regioselective manner by palladium acetate catalyzed reaction of 3-sulfonato- or 3-bromo-Δ³-cephems with dialkylzinc or vinyltributyltin. A new access to 3-alkyl-Δ³-cephems is opened, starting from the allenyl compound 10.