Highly Diastereoselective Pinacol Coupling of Aldehydes Catalyzed by Titanium-Schiff Base Complexes

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• 作者：Bandini ; Marco ; Cozzi ; Pier Giorgio ; Morganti ; Stefano ; Umani-Ronchi ; Achille
• 刊名：Tetrahedron Letters
• 出版年：1999
• 出版时间：March 5, 1999
• 年：1999
• 卷：40
• 期：10
• 页码：1997-2000
• 全文大小：149 K

文摘

A new effective methodology for a highly diastereoselective pinacol coupling of aldehydes is described. The method employes 3 mol % of a complex prepared in situ from TiCl₄(THF)₂ and a Schiff base in acetonitrile. The catalytic cycle is realized with Me₃SiCl and Mn as reducing agent. The dependence of the diastereoselectivity on the Schiff base used is reported.