Zinc triflate–bis-oxazoline complexes as chiral catalysts: enantioselective reduction of α-alkoxy-ketones with catecholborane

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• 作者：Bandini ; Marco ; Cozzi ; Pier Giorgio ; de Angelis ; Meri ; Umani-Ronchi ; Achille
• 关键词：asymmetric reactions ; catalysis ; ketones ; reduction
• 刊名：Tetrahedron Letters
• 出版年：2000
• 出版时间：March 4, 2000
• 年：2000
• 卷：41
• 期：10
• 页码：1601-1605
• 全文大小：183 K

文摘

A new methodology for the catalytic enantioselective reduction of α-alkoxy-ketones is described. The procedure employes Zn(OTf)₂–bis-oxazoline complexes (8–10 mol % ) as catalysts and catecholborane as the reducing agent. The reaction, carried out in CH₂Cl₂ at 0°C, affords the α-alkoxy-alcohols in high yields and with good enantioselectivity.