Transcription Factor EB Controls Metabolic Flexibility during Exercise

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• 作者：Gelsomina Mansueto¹ ; Andrea Armani² ; Carlo Viscomi³ ; ⁴ ; Luca D&rsquo ; Orsi¹ ; Rossella De Cegli¹ ; Elena V. Polishchuk¹ ; Costanza Lamperti⁴ ; Ivano Di Meo⁴ ; Vanina Romanello² ; ⁵ ; Silvia Marchet⁴ ; Pradip K. Saha⁶ ; Haihong Zong⁷ ; ⁸ ; Bert Blaauw² ; Francesca Solagna² ; Caterina Tezze² ; Paolo Grumati⁹ ; Paolo Bonaldo⁹ ; Jeffrey E. Pessin⁸ ; Massimo Zeviani³ ; ⁴ ; Marco Sandri¹ ; ² ; ⁵ ; ¹³ ; ^{marco.sandri@unipd.it} ; Andrea Ballabio¹ ; ¹⁰ ; ¹¹ ; ¹² ; ^{ballabio@tigem.it}
• 关键词：TFEB ; autophagy ; exercise ; glucose ; mitochondria ; diabetes ; mitochondrial fusion ; PGC1alpha ; metabolic flexibility ; insulin
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：182-196
• 全文大小：5856 K
• 卷排序：25

文摘

TFEB regulates mitochondrial biogenesis and function in muscle Glucose homeostasis in skeletal muscle requires TFEB The effects of TFEB on muscle metabolism are independent from PGC1α TFEB coordinates metabolic flexibility during physical exercise