Induced neural stem cells modulate microglia activation states via CXCL12/CXCR4 signaling

详细信息    查看全文

• 作者：Mou Gao^a ; ^b ; Qin Dong^c ; Hui Yao^b ; Yan Zhang^b ; Yang Yang^b ; Yuanyuan Dang^b ; Hongtian Zhang^b ; Zhijun Yang^b ; Minhui Xu^a ; ^{dpmhxu@126.com} ; Ruxiang Xu^b ; ^{jzprofxu@126.com}
• 关键词：Induced neural stem cell ; Microglia ; CXCR4 ; Closed head injury ; Immunomodulation
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：59
• 期：Complete
• 页码：288-299
• 全文大小：6157 K
• 卷排序：59

文摘

INSCs affect microglia activation and the acquisition of neuroprotective phenotypes. INSCs modulate microglia phenotypes via CXCL12/CXCR4 signaling. INSCs promote neurological functional recovery in CHI mice. INSCs reduce cerebral edema and cell death in CHI mice. INSCs influence neuronal survival and reactive astrogliosis in CHI mice.