DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants

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DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants

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作者：Vickie Kwan¹ ; ² ; Durga Praveen Meka³ ; Sean H. White¹ ; ² ; Claudia L. Hung² ; Nicholas T. Holzapfel¹ ; ² ; Susan Walker⁴ ; ⁵ ; Nadeem Murtaza¹ ; ² ; Brianna K. Unda¹ ; ² ; Birgit Schwanke³ ; Ryan K.C. Yuen⁴ ; ⁵ ; Kendra Habing¹ ; ² ; Chloe Milsom¹ ; ² ; Kristin J. Hope¹ ; ² ; Ray Truant² ; Stephen W. Scherer⁴ ; ⁵ ; Froylan Calderon de Anda³ ; Karun K. Singh¹ ; ² ; ⁶ ; ^{singhk2@mcmaster.ca" class="auth_mail" title="E-mail the corresponding author}
关键词：dendrite growth ; dendritic spine ; autism spectrum disorder ; actin ; cytoskeleton ; neurodevelopment ; genetic variants ; MARK1 ; excitatory synapse ; Wnt signaling
刊名：Cell Reports
出版年：2016
出版时间：8 November 2016
年：2016
卷：17
期：7
页码：1892-1904
全文大小：4251 K

文摘

class="label">•: DIXDC1 is a regulator of dendrite and spine development
class="label">•: MARK1 phosphorylates DIXDC1 isoforms to regulate dendrite and spine development
class="label">•: Phosphorylation of DIXDC1 isoform 1 regulates cytoskeletal dynamics
class="label">•: ASD variants in DIXDC1 isoform 1 impair phosphorylation and neuronal morphology

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