Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice

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• 作者：Dwight A.L. Mattocks^a ; Samantha J. Mentch^b ; Jelena Shneyder^a ; Gene P. Ables^a ; Dongxiao Sun^c ; John P. Richie Jr.^d ; Jason W. Locasale^b ; Sailendra N. Nichenametla^a ; ^{snichenametla@orentreich.org}
• 关键词：MR ; methionine restriction ; SAM ; S-adenosylmethionine ; SAH ; S-adenosylhomocysteine ; DNMT1 ; DNA methyltransferase-1 ; CD ; control diet ; GM ; global DNA methylation ; GSM ; gene-specific methylation ; LINE-1 ; long interspersed nuclear elements-1 ; 5-meC ; methylated cytosine in DNA ; 5-C ; unmethylated cytosines in DNA
• 刊名：Experimental Gerontology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：88
• 期：Complete
• 页码：1-8
• 全文大小：576 K
• 卷排序：88

文摘

Effect of methionine restriction (MR) on DNA methylation was investigated. MR did not alter hepatic global DNA methylation (GM) in young mice (8 weeks). In adults (12 months), MR restored age-related decrease in hepatic GM to the levels observed in young mice. Changes in GM were negatively correlated with S-adenosylhomocysteine levels. Findings suggest that altered GM might be contributing to MR-induced lifespan extension.