Objective
We sought to estimate the risk o
f large
for gestational age (LGA) across categories o
f glucose tolerance.
Study Design
In a cohort of 89,141 participants, women without gestational diabetes mellitus (GDM) were categorized by their screening and diagnostic test results; those with GDM were categorized as meeting the National Diabetes Data Group or only the American Diabetes Association (ADA) criteria. Multivariable logistic regression models estimated the risk of LGA; screening values 5.5-6.0 mmol/L comprised the referent.
Results
In women without GDM, the odds ratio for LGA was 1.89 (95 % confidence interval [CI], 1.45–2.45) for fasting, 1.57 (95 % CI, 1.31–1.89) for 1-hour, 1.60 (95 % CI, 1.33–1.93) for 2-hour, and 1.62 (95 % CI, 1.23–2.14) for 3-hour values meeting the ADA time point–specific thresholds.
Conclusion
For GDM identified in a 2-step procedure, our findings support the use of isolated abnormal fasting values according to the ADA threshold in identifying women who could benefit from treatment.
