From the exposome to mechanistic understanding of chemical-induced adverse effects

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• 作者：Beate I. Escher^a ; ¹ ; ^{beate.escher@ufz.de} ; Jö ; rg Hackermü ; ller^a ; ¹ ; Tobias Polte^a ; ¹ ; Stefan Scholz^a ; ¹ ; Achim Aigner^b ; Rolf Altenburger^a ; Alexander Bö ; hme^a ; Stephanie K. Bopp^c ; Werner Brack^a ; Wibke Busch^a ; Marc Chadeau-Hyam^d ; Adrian Covaci^e ; Adolf Eisenträ ; ger^f ; James J. Galligan^g ; Natalia Garcia-Reyero^h ; ⁱ ; Thomas Hartung^j ; ^k ; Michaela Hein^a ; Gunda Herberth^a ; Annika Jahnke^a ; Jos Kleinjans^l ; Nils Klü ; ver^a ; Martin Krauss^a ; Marja Lamoree^m ; Irina Lehmann^a ; Till Luckenbach^a ; Gary W. Millerⁿ ; Andrea Mü ; ller^a ; David H. Phillips^o ; Thorsten Reemtsma^a ; Ulrike Rolle-Kampczyk^a ; Gerrit Schü ; ü ; rmann^a ; ^p ; Benno Schwikowski^q ; Yu-Mei Tan^r ; Saskia Trump^a ; Susanne Walter-Rohde^f ; John F. Wambaugh^s
• 关键词：AEP ; Aggregate exposure pathway ; AO ; Adverse outcome ; AOP ; adverse outcome pathway ; EWAS ; exposome-wide association studies ; KE ; key event ; HTS ; high throughput screening ; MIE ; molecular initiating event ; TD ; toxicodynamic ; TK ; toxicokinetic
• 刊名：Environment International
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：99
• 期：Complete
• 页码：97-106
• 全文大小：1083 K
• 卷排序：99

文摘

Mechanistic understanding of the causal links between exposure and adverse effects can be improved. AOP concept enhances understanding the exposome and its impact on adverse outcome. Exposome and AOP can connect human health and environmental risk assessment. Mixtures should be included in AOP concept.