Deficiency of succinyl-CoA synthetase α subunit delays development, impairs locomotor activity and reduces survival under starvation in Drosophila

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• 作者：Xiuming Quan^a ; Yukiko Sato-Miyata^a ; Manabu Tsuda^b ; Keigo Muramatsu^a ; Tsunaki Asano^a ; Satomi Takeo^a ; Toshiro Aigaki^a ; ^{aigaki-toshiro@tmu.ac.jp}
• 关键词：Succinyl-CoA synthetase α subunit ; SCS deficiency ; Energy metabolism ; Developmental delay ; Glycogen breakdown
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：566-571
• 全文大小：876 K
• 卷排序：483

文摘

Succinyl-CoA synthetase alpha (SCSα) deficiency was generated in Drosophila. SCS deficient flies contain a high level of succinyl-CoA. SCS deficiency alters the levels of metabolites in TCA cycle and glycolysis. SCS deficiency causes developmental delays and glycogen breakdown. SCS deficiency impairs locomotor activity and reduces survival under starvation.