A novel mechanism of functional cooperativity regulation by thiol redox status in a dimeric inorganic pyrophosphatase

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• 作者：Evenilton P. Costa^a ; Arnoldo R. Faç ; anha^a ; Criscila S. Cruz^a ; ^b ; Jhenifer N. Silva^a ; Josias A. Machado^a ; Gabriel M. Carvalho^a ; Mariana R. Fernandes^a ; Renato Martins^a ; Eldo Campos^b ; Nelilma C. Romeiro^b ; Naftaly W. Githaka^c ; Satoru Konnai^d ; Kazuhiko Ohashi^d ; Itabajara S. Vaz Jr^e ; Carlos Logullo^a ; ^{logullo@uenf.br}
• 关键词：Thiol redox status ; Pyrophosphatase ; Cooperativity ; Embryogenesis ; Disulfide bond formation ; Metabolism
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1861
• 期：1
• 页码：2922-2933
• 全文大小：2126 K
• 卷排序：1861

文摘

A pyrophosphatase is regulated by dimeric cooperativity according to the cysteine redox status. The results are carefully addressing the participation of pyrophosphatase during embryogenesis. A new angle of redox control by disulfide bond formation on enzymatic regulation