HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4<sup>+</sup> T Cells

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HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4⁺ T Cells

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作者：Jolien Vermeire¹ ; ⁴ ; Ferdinand Roesch² ; ⁴ ; Daniel Sauter³ ; Ré ; jane Rua² ; ⁵ ; Dominik Hotter³ ; Anouk Van Nuffel¹ ; Hanne Vanderstraeten¹ ; Evelien Naessens¹ ; Veronica Iannucci¹ ; Alessia Landi¹ ; Wojciech Witkowski¹ ; Ann Baeyens¹ ; Frank Kirchhoff³ ; Bruno Verhasselt¹ ; ⁶ ; ^{bruno.verhasselt@ugent.be" class="auth_mail" title="E-mail the corresponding author}
关键词：HIV ; Vpr ; Vpu ; interferon ; cGAS ; T cells ; dendritic cells ; innate sensing ; NF-κB ; CD4
刊名：Cell Reports
出版年：2016
出版时间：4 October 2016
年：2016
卷：17
期：2
页码：413-424
全文大小：2219 K

文摘

•: HIV infection triggers a type I interferon (IFN-I) response in primary CD4⁺ T cells
•: IFN-I induction requires integration of HIV-1 and is mediated by cGAS
•: HIV-1 Vpr potentiates and Vpu suppresses IFN-I induction

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