Prenatal mercury exposure, neurodevelopment and apolipoprotein E genetic polymorphism

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• 作者：Janja Snoj Tratnik^a ; ^h ; Ingrid Falnoga^a ; Ajda Trdin^a ; ^h ; Darja Mazej^a ; Vesna Fajon^a ; ^h ; Ana Miklavčič^a ; Alfred B. Kobal^b ; Jo&scaron ; ko Osredkar^c ; Alenka Se&scaron ; ek Bri&scaron ; ki^c ; Mladen Krsnik^c ; David Neubauer^d ; Jana Kodrič^d ; Sta&scaron ; a Stropnik^d ; David Gosar^d ; Petra Le&scaron ; nik Musek^d ; Janja Marc^e ; Simona Jurkovič Mlakar^e ; Oleg Petrović^f ; Inge Vla&scaron ; ić-Cicvarić^f ; Igor Prpić^f ; Ana Milardović^f ; Jelena Radić Ni&scaron ; ević^f ; Danijela Vuković^f ; Elizabeta Fi&scaron ; ić^f ; Zdravko &Scaron ; pirić^g ; Milena Horvat^a ; ^h ; ^{milena.horvat@ijs.si}
• 关键词：APOE ; Apolipoprotein E ; Apoe ; apolipoprotein E gene ; BDNF ; brain-derived Neurotrophic Factor ; BSID-II ; Bayley Scales of Infant Development ; Second Edition ; Bayley-III ; Bayley Scales of Infant and Toddler Development ; Third Edition ; CVAAS ; Cold Vapour Atomic Absorption Spectrometry ; GM ; geometric mean ; Max ; maximum ; Min ; minimum ; LOD ; limit of detection ; PHIME ; Public Health Impact of Long-term Low-level Mixed Element Exposure in Susceptible Population Strata ; PGR ; progesterone receptor ; PON1 ; Pa
• 刊名：Environmental Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：152
• 期：Complete
• 页码：375-385
• 全文大小：405 K
• 卷排序：152

文摘

Apoe ε4 carriers showed negative association between cord blood Hg and cognitive score. Fine motor score was negatively associated with cord blood Hg in all children. Gene-environment interaction was confirmed for the cognitive score. .Se and Pb levels confounded the association between Hg and neurodevelopment.