Synthesis, characterization and biological evaluation of novel Ru(II)-arene complexes containing intercalating ligands

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Synthesis, characterization and biological evaluation of novel Ru(II)-arene complexes containing intercalating ligands

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作者：Stefan Nikolić^a ; ¹ ; Loganathan Rangasamy^b ; ¹ ; Nevenka Gligorijević^c ; Sandra Aranđelović^c ; Sini&scaron ; a Radulović^c ; Gilles Gasser^b ; ^{gilles.gasser@chem.uzh.ch" class="auth_mail" title="E-mail the corresponding author} ; ; Sanja Grgurić-&Scaron ; ipka^a ; ^{sanjag@chem.bg.ac.rs" class="auth_mail" title="E-mail the corresponding author} ;
关键词：Anticancer agents ; Bioorganometallic chemistry ; DNA intercalating ligand ; Medicinal inorganic chemistry ; Ruthenium(II)&ndash ; arene complex
刊名：Journal of Inorganic Biochemistry
出版年：2016
出版时间：July 2016
年：2016
卷：160
期：Complete
页码：156-165
全文大小：770 K

文摘

•: Three new organometallic Ru(II) complexes were synthesized and characterized.
•: Two complexes were highly toxic against three cancer cell lines and one non-tumor cell line.
•: The mechanism of action of the most potent complex was studied.
•: Intracellular accumulation and DNA binding were detected for the most potent complex.

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