Effect of fingolimod treatment on circulating miR-15b, miR23a and miR-223 levels in patients with multiple sclerosis

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Effect of fingolimod treatment on circulating miR-15b, miR23a and miR-223 levels in patients with multiple sclerosis

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作者：Chiara Fenoglio ; ^{chiara.fenoglio@unimi.it" class="auth_mail" title="E-mail the corresponding author} ; Milena De Riz ^{milena.deriz@unimi.it" class="auth_mail" title="E-mail the corresponding author} ; Anna M. Pietroboni ^{anna.pietroboni@unimi.it" class="auth_mail" title="E-mail the corresponding author} ; Alberto Calvi ^{alberto.calvi@unimi.it" class="auth_mail" title="E-mail the corresponding author} ; Maria Serpente ^{maria.serpente@policlinico.mi.it" class="auth_mail" title="E-mail the corresponding author} ; Sara M.G. Cioffi ^{sara.cioffi@unimi.it" class="auth_mail" title="E-mail the corresponding author} ; Marina Arcaro ^{marina.arcaro@unimi.it" class="auth_mail" title="E-mail the corresponding author} ; Emanuela Oldoni ^{emanuela.oldoni@unimi.it" class="auth_mail" title="E-mail the corresponding author} ; Elio Scarpini ^{elio.scarpini@unimi.itc" class="auth_mail" title="E-mail the corresponding author} ; Daniela Galimberti ^{daniela.galimberti@unimi.it" class="auth_mail" title="E-mail the corresponding author}
关键词：Multiple sclerosis ; MicroRNA ; Fingolimod ; Biomarker
刊名：Journal of Neuroimmunology
出版年：2016
出版时间：15 October 2016
年：2016
卷：299
期：Complete
页码：81-83
全文大小：284 K

文摘

•: MicroRNAs (miRNAs) have recently found to be dysregulated in serum from MS patients.
•: Specific miRNA levels can be modulated by common drugs used in MS.
•: miR-15b, miR-23a and miR-223 levels resulted significantly downregulated in patients.
•: A recovery in miRNA levels was found after 6 months of fingolimod treatment.
•: The correlation between miRNA levels and clinical variables did not give significant results.

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