Asymmetrical flow field-flow fractionation coupled with multi-angle laser light scattering for stability comparison of virus-like particles in different solution environments

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Asymmetrical flow field-flow fractionation coupled with multi-angle laser light scattering for stability comparison of virus-like particles in different solution environments

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作者：Yi Chen^a ; ^b ; ¹ ; Yan Zhang^a ; ¹ ; Yuefang Zhou^a ; Jian Luo^a ; Zhiguo Su^a ; ^c ; ^{zgsu@ipe.ac.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：Asymmetrical flow field-flow fractionation ; Virus-like particle ; Antigenicity ; Hepatitis B surface antigen ; Aggregation
刊名：Vaccine
出版年：2016
出版时间：8 June 2016
年：2016
卷：34
期：27
页码：3164-3170
全文大小：2421 K

文摘

•: HBsAg particles expressed by CHO and Hansenula polymorpha were compared by AF4-MALLS.
•: Stabilities of CHO-HBsAg and Hans-HBsAg under different solution environments were described.
•: CHO-HBsAg was more homogeneous and more stable under different solution environments than Hans-HBsAg.

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