Cochlear changes in presbycusis with tinnitus

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• 作者：Kyoichi Terao MD ; PhD^a ; ^b ; ^d ; Sebahattin Cureoglu MD^a ; ^c ; ^{cureo003@umn.edu"" rel=""nofollow} ; Patricia A. Schachern BS^a ; Norimasa Morita MD ; PhD^a ; ^b ; Shigenobu Nomiya MD ; PhD^a ; ^b ; Armin F. Deroee MD^a ; ^b ; Katsumi Doi MD ; PhD^d ; Kazunori Mori MD ; PhD^d ; Kiyotaka Murata MD ; PhD^d ; Michael M. Paparella MD^a ; ^b ; ^c
• 刊名：American Journal of Otolaryngology
• 出版年：2011
• 出版时间：May-June 2011
• 年：2011
• 卷：32
• 期：3
• 页码：215-220
• 全文大小：743 K

文摘

Objectives

The pathophysiology of tinnitus is obscure and its treatment is therefore elusive. Significant progress in this field can only be achieved by determining the mechanisms of tinnitus generation, and thus, histopathologic findings of the cochlea in presbycusis with tinnitus become crucial. We revealed the histopathologic findings of the cochlea in subjects with presbycusis and tinnitus.

Material and methods

The subjects were divided into 2 groups, presbycusis with tinnitus (tinnitus) group and presbycusis without tinnitus (control) group, with each group comprising 8 temporal bones from 8 subjects. We quantitatively analyzed the number of spiral ganglion cells, loss of cochlear inner and outer hair cells, and areas of the stria vascularis and spiral ligament.

Results

There was a significantly greater loss of outer hair cells in the tinnitus group compared with the control group in the basal and upper middle turns. The stria vascularis was more atrophic in the tinnitus group compared with the control group in the basal turn.

Conclusions

Tinnitus is more common in patients with presbycusis who have more severe degeneration of outer hair cells and stria vascularis.