Metagenomic Sequencing with Strain-Level Resolution Implicates Uropathogenic E. coli in Necrotizing Enterocolitis and Mortality in Preterm Infants

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Metagenomic Sequencing with Strain-Level Resolution Implicates Uropathogenic E. coli in Necrotizing Enterocolitis and Mortality in Preterm Infants

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作者：Doyle V. Ward¹ ; ⁴ ; ^{doyle.ward@umassmed.edu" class="auth_mail" title="E-mail the corresponding author} ; Matthias Scholz² ; ⁴ ; Moreno Zolfo² ; Diana H. Taft³ ; Kurt R. Schibler³ ; Adrian Tett² ; Nicola Segata² ; ⁵ ; Ardythe L. Morrow³ ; ⁵
刊名：Cell Reports
出版年：2016
出版时间：29 March 2016
年：2016
卷：14
期：12
页码：2912-2924
全文大小：1775 K

文摘

•: Uropathogenic E. coli is a risk factor for necrotizing enterocolitis and death
•: Assembly-free metagenomic methods enable strain-level analysis and epidemiology
•: Identification of E. coli strains may be critical to understanding NEC pathology

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