Lipopolysaccharide administration induces sex-dependent behavioural and serotonergic neurochemical signatures in mice

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• 作者：Jonathon Sens ; Eric Schneider ; Joseph Mauch ; Anna Schaffstein ; Sara Mohamed ; Kathryn Fasoli ; Joseph Saurine ; Aikaterini Britzolaki ; Connor Thelen ; Pothitos M. Pitychoutis ; ^{ppitychoutis1@udayton.edu}
• 关键词：5-HIAA ; 5-hydroxy-indoleacetic acid ; 5-HT ; serotonin ; 5-hydroxytryptamine ; ANOVA ; analysis of variance ; BDNF ; brain-derived neurotrophic factor ; CNS ; central nervous system ; DOPAC ; dihydroxyphenylacetic acid ; FST ; forced swim test ; GR ; glucocorticoid receptor ; HPLC ; high performance liquid chromatography ; HVA ; homovanillic acid ; HPA ; hypothalamus-pituitary-adrenal ; IDO ; indolamine 2 ; 3-dioxyenase ; IL-6 ; interleukin-6 ; IQ ; interquartile range ; LPS ; lipopolysaccharide ; MAMP ; microbial-associated mo
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：153
• 期：Complete
• 页码：168-181
• 全文大小：1793 K
• 卷排序：153

文摘

LPS induces sex-dependent behavioural effects in C57BL/6J mice. Anhedonia and locomotor activity were equally impaired in the two sexes. LPS-treated females were more vulnerable in the splash test and males to anorexia. LPS induced sustained serotonergic hyperactivity in the female mouse brain.