Parallel reaction monitoring of clinical Mycobacterium tuberculosis lineages reveals pre-existent markers of rifampicin tolerance in the emerging Beijing lineage

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Parallel reaction monitoring of clinical Mycobacterium tuberculosis lineages reveals pre-existent markers of rifampicin tolerance in the emerging Beijing lineage

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作者：Jeroen de Keijzer^a ; ^{j.de_keijzer@lumc.nl" class="auth_mail" title="E-mail the corresponding author} ; Arnout Mulder^b ; Arnoud H. de Ru^a ; ^c ; Dick van Soolingen^b ; ^d ; ¹ ; Peter A. van Veelen^a ; ^c ; ¹
关键词：CAS ; Central Asian strains ; DDA ; data dependent acquisition ; EAI ; East-African Indian ; FDR ; false discovery rate ; FASP ; filter aided sample preparation ; MIC ; minimal inhibitory concentration ; MDR-TB ; multidrug resistant tuberculosis ; MGIT ; mycobacterial growth indicator tube ; MIRU ; mycobacterial interspersed repeat units ; nsSNP ; non synonymous single nucleotide polymorphisms ; PRM ; parallel reaction monitoring ; RRDR ; rifampicin resistance determining region ; SIL ; stable isotopically labelled ; SCX
刊名：Journal of Proteomics
出版年：2017
出版时间：6 January 2017
年：2017
卷：150
期：Complete
页码：9-17
全文大小：952 K

文摘

•: The proteomic composition of M. tuberculosis Beijing and H37Rv were compared.
•: Both M. tuberculosis Beijing and H37Rv induce dormancy proteins as a shared response upon exposure to rifampicin.
•: The abundance of PhoPR regulon proteins is conserved in clinical strains of M. tuberculosis.
•: The dormancy regulators Rv3132c/devS and Rv3133c/devR are more abundant in M. tuberculosis Beijing.