Methylation of Septin9 mediated by DNMT3a enhances hepatic stellate cells activation and liver fibrogenesis

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• 作者：Yuting Wu ^{wuyuting1302@sina.com} ; Fangtian Bu ; Haixia Yu ; Wanxia Li ; Cheng Huang ; Xiaoming Meng ; Lei Zhang ; Taotao Ma ; Jun Li ; ^{lj@ahmu.edu.cn}
• 关键词：Sept9 ; septin9 ; ECM ; extracellular matrix ; HSCs ; hepatic stellate cells ; α-SMA ; α-smooth muscle actin ; Col1a1 ; type I collagen ; TGF-β1 ; transforming growth factor-β1 ; HCC ; hepatocellular cancer ; 5-azadC ; 5-aza-2&prime ; -deoxycytidine ; CRC ; colorectal cancer ; DNMTs ; DNA methyltransferase enzymes ; RRBS ; reduced representation bisulfite sequencing ; BSP ; bisulfite pyrosequencing PCR ; MSP ; methylation-specific PCR
• 刊名：Toxicology and Applied Pharmacology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：315
• 期：Complete
• 页码：35-49
• 全文大小：3227 K
• 卷排序：315

文摘

This is the first report of Sept9 methylation and function in liver fibrosis. Ectopic expression of Sept9 could block the liver fibrogenesis. DNMT3a might be responsible for the suppression of Sept9 in liver fibrosis.