Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

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Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

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作者：Pascal D. Johann¹ ; ² ; ³ ; ³² ; Serap Erkek¹ ; ² ; ⁴ ; ³² ; Marc Zapatka² ; ⁵ ; Kornelius Kerl⁶ ; Ivo Buchhalter⁷ ; Volker Hovestadt² ; ⁵ ; David T.W. Jones¹ ; ² ; Dominik Sturm¹ ; ² ; ³ ; Carl Hermann⁷ ; Maia Segura Wang⁴ ; Andrey Korshunov⁸ ; ⁹ ; Marina Rhyzova¹⁰ ; Susanne Grö ; bner¹ ; Sebastian Brabetz¹ ; Lukas Chavez¹ ; Susanne Bens¹¹ ; Stefan Grö ; schel¹² ; Fabian Kratochwil¹ ; ² ; Andrea Wittmann¹ ; ² ; Laura Sieber¹ ; ² ; Christina Geö ; rg¹² ; Stefan Wolf¹³ ; Katja Beck² ; ⁵ ; Florian Oyen¹⁴ ; David Capper⁸ ; ⁹ ; Peter van Sluis¹⁵ ; Richard Volckmann¹⁵ ; Jan Koster¹⁵ ; Rogier Versteeg¹⁵ ; Andreas von Deimling⁸ ; ⁹ ; Till Milde³ ; ¹⁶ ; Olaf Witt³ ; ¹⁶ ; Andreas E. Kulozik³ ; Martin Ebinger¹⁷ ; Tarek Shalaby¹⁸ ; Michael Grotzer¹⁸ ; David Sumerauer¹⁹ ; Josef Zamecnik²⁰ ; Jaume Mora²¹ ; Nada Jabado²² ; Michael D. Taylor²³ ; Annie Huang²³ ; Eleonora Aronica²⁴ ; Anna Bertoni⁵ ; Bernhard Radlwimmer⁵ ; Torsten Pietsch²⁵ ; Ulrich Schü ; ller²⁶ ; Reinhard Schneppenheim¹⁴ ; Paul A. Northcott¹ ; ² ; Jan O. Korbel⁴
刊名：Cancer Cell
出版年：2016
出版时间：14 March 2016
年：2016
卷：29
期：3
页码：379-393
全文大小：6068 K

文摘

•: ATRTs are comprised of three epigenetically distinct subgroups: TYR, SHH, and MYC
•: H3K27Ac enhancer landscapes reveal ATRT subgroup-specific regulatory networks
•: Regulatory networks lead to identification of potential therapeutic targets
•: Epigenetic profiles point at distinct cellular origins of ATRT subgroups

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