Improved Outcome of a Reduced Toxicity-Fludarabine, Cyclophosphamide, plus Antithymocyte Globulin Conditioning Regimen for Unrelated Donor Transplantation in Severe Aplastic Anemia: Comparison of 2 Multicenter Prospective Studies

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Improved Outcome of a Reduced Toxicity-Fludarabine, Cyclophosphamide, plus Antithymocyte Globulin Conditioning Regimen for Unrelated Donor Transplantation in Severe Aplastic Anemia: Comparison of 2 Multicenter Prospective Studies

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作者：Hyoung Jin Kang¹ ; ^&dagger ; ; Kyung Taek Hong¹ ; ^&dagger ; ; Ji Won Lee¹ ; Hyery Kim¹ ; Kyung Duk Park¹ ; Hee Young Shin¹ ; Soo Hyun Lee² ; Keon Hee Yoo² ; Ki Woong Sung² ; Hong Hoe Koo² ; Jae Wook Lee³ ; Nak Gyun Chung³ ; Bin Cho³ ; Hack Ki Kim³ ; Kyung Nam Koh⁴ ; Ho Joon Im⁴ ; Jong Jin Seo⁴ ; Hyun Joo Jung⁵ ; Jun Eun Park⁵ ; Young Ho Lee⁶ ; Young Tak Lim⁷ ; Yeon Jung Lim⁸ ; Sun Young Kim⁸ ; Eun Sun Yoo⁹ ; Kyung Ha Ryu⁹ ; Jae Hee Lee¹⁰ ; Jeong-A Park¹¹ ; Sang Kyu Park¹² ; Hyo Seop Ahn¹ ; ^{hsahn@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; on behalf of The Korean Society of Pediatric Hematology-Oncology
关键词：Severe aplastic anemia ; Unrelated donor ; Fludarabine ; Cyclophosphamide ; Thymoglobulin ; Antithymocyte globulin (ATG)
刊名：Biology of Blood and Marrow Transplantation
出版年：2016
出版时间：August 2016
年：2016
卷：22
期：8
页码：1455-1459
全文大小：383 K

文摘

•: The optimal conditioning regimen for unrelated donor HSCT in SAA has not been defined.
•: The 2 regimens using FLU, Cy, and ATG were compared.
•: The regimen using a reduced dose of Cy and an increased dose of FLU showed better outcomes.
•: A FLU, Cy, and ATG regimen with reduced toxicity could be optimal for unrelated donor HSCT in SAA.