A critical discussion on diet, genomic mutations and repair mechanisms in colon carcinogenesis

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• 作者：Juliana Yumi Sakita^a ; ¹ ; Bianca Gasparotto^a ; ¹ ; Sergio Britto Garcia^b ; Sergio Akira Uyemura^a ; Vinicius Kannen^a ; ^{vinicius.kannen@fcfrp.usp.br}
• 关键词：Xenobiotics ; Pollutants ; Environment ; Bowels ; Proliferation
• 刊名：Toxicology Letters
• 出版年：2017
• 出版时间：4 January 2017
• 年：2017
• 卷：265
• 期：Complete
• 页码：106-116
• 全文大小：1342 K
• 卷排序：265

文摘

Western diet has an uncountable number of chemicals that affect humans. Combining low concentrations of various chemicals leads to more powerful effects than an isolated exposure. Low and late-cell cycle expressed genes are prone to undergo mutation. Detection and repair mechanisms have a specific threshold to be activated throughout the G2/M phase. Reactivation of these mechanisms during the M phase promotes genomic instability.