Novel genipin crosslinked atorvastatin loaded sericin nanoparticles for their enhanced antihyperlipidemic activity

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Novel genipin crosslinked atorvastatin loaded sericin nanoparticles for their enhanced antihyperlipidemic activity

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作者：Jovita Kanoujia ; Mahendra Singh ; Pooja Singh ; Shubhini A. Saraf ; ^{shubhini.saraf@gmail.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Seri ; sericin ; NPs ; nanoparticles ; Seri-Atr NPs ; sericin encapsulated atorvastatin nanoparticles ; Gn ; genipin ; DA ; desolvating agents ; Atr ; atorvastatin ; DL ; drug loading ; EE ; entrapment efficiency ; TG ; triacylglycerols ; TC ; total cholesterol ; HDL ; high density lipoprotein ; LDL ; low density lipoprotein ; VLDL ; very low-density lipoprotein cholesterol ; CD ; crosslinking degree ; CT ; crosslinking time ; CMC ; carboxymethyl cellulose ; Cmax ; maximum plasma concentration ; Tmax ; time required to reach maxi
刊名：Materials Science & Engineering C
出版年：2016
出版时间：1 December 2016
年：2016
卷：69
期：Complete
页码：967-976
全文大小：1421 K

文摘

•: Sericin is used as a natural, safe, biomaterial for successful delivery of atorvastatin.
•: Genipin crosslinked sericin nanoparticles were prepared for biomedical application.
•: Encapsulation of atorvastatin in sericin nanoparticles substantially enhanced its antihyperlipidemic activity.
•: Sericin nanoparticles have good controlled release properties for Atr in vitro.

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