The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing

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The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing

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作者：Jane E. Sexton^a ; ^{jane.sexton.09@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Terri Desmonds^b ; Kathryn Quick^a ; Ruth Taylor^c ; Joel Abramowitz^d ; Andy Forge^c ; Corné ; J. Kros^b ; ^e ; Lutz Birnbaumer^d ; John N. Wood^a
关键词：DKO ; double knockout mice ; QuadKO ; quadruple knockout mice
刊名：Neuroscience Letters
出版年：2016
出版时间：1 January 2016
年：2016
卷：610
期：Complete
页码：36-42
全文大小：1632 K

文摘

•: The contribution of multiple TRPC channels on mechanosensory function is demonstrated.
•: We observe a critical role for TRPC channels in touch sensation.
•: TRPC channels contribute to cutaneous and auditory mechanosensation in a combinatorial manner, but have no direct role in cochlear mechanotransduction.

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