Secreted factors from adipose tissue-derived mesenchymal stem cells suppress oxygen/glucose deprivation-induced cardiomyocyte cell death via furin/PCSK-like enzyme activity

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Secreted factors from adipose tissue-derived mesenchymal stem cells suppress oxygen/glucose deprivation-induced cardiomyocyte cell death via furin/PCSK-like enzyme activity

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作者：Yuki Tachida ; Koji Suda ; Hiroyuki Nagase ; Kohei Shimada ; Fujio Isono ; Hideki Kobayashi ; ^{kobayashi.hideki.gc@daiichisankyo.co.jp" class="auth_mail" title="E-mail the corresponding author}
关键词：Mesenchymal stem cells ; Conditioned medium ; Cardioprotection ; Furin/PCSK5
刊名：Biochemistry and Biophysics Reports
出版年：2016
出版时间：September 2016
年：2016
卷：7
期：Complete
页码：266-272
全文大小：1076 K

文摘

•: ASC-CM protects against OGD-induced cell death of adult cardiomyocytes.
•: Furin/PCSK enzyme activity is protective against OGD-induced cell death.
•: PCSK5A is the main component of cardioprotective activity of ASC-CM.

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