Benzotriazoles Reactivate Latent HIV-1 through Inactivation of STAT5 SUMOylation

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• 作者：Alberto Bosque¹ ; ⁷ ; ⁸ ; ^{abosque@gwu.edu} ; Kyle A. Nilson² ; ³ ; Amanda B. Macedo¹ ; ⁷ ; Adam M. Spivak⁴ ; Nancie M. Archin⁵ ; Ryan M. Van Wagoner⁶ ; Laura J. Martins¹ ; Camille L. Novis¹ ; Matthew A. Szaniawski¹ ; Chris M. Ireland⁶ ; David M. Margolis⁵ ; David H. Price² ; ³ ; Vicente Planelles¹ ; ^{vicente.planelles@path.utah.edu}
• 关键词：HIV-1 latency ; HIV-1 reservoir ; STAT5 ; SUMOylation ; latency reversing agent ; shock and kill ; benzotriazoles
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：31 January 2017
• 年：2017
• 卷：18
• 期：5
• 页码：1324-1334
• 全文大小：2816 K
• 卷排序：18

文摘

Benzotriazoles reactivate and decrease latent HIV-1 both in vitro and ex vivo Reactivation is independent of T cell proliferation or global immune activation Inhibition of STAT5 SUMOylation is the main target of benzotriazoles Benzotriazoles increase binding of STAT5 to the HIV-1 LTR