Potent anticancer activity of a new bismuth (III) complex against human lung cancer cells

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• 作者：Ruizhuo Ouyang^a ; ¹ ; ^{ouyangrz@usst.edu.cn} ; Yang Yang^a ; ¹ ; Xiao Tong^b ; ¹ ; Kai Feng^a ; Yaoqin Yang^b ; Huihong Tao^b ; Xiaoshen Zhang^b ; Tianyu Zong^a ; Penghui Cao^a ; Fei Xiong^a ; Ning Guo^a ; Yuhao Li^a ; Yuqing Miao^a ; ^{yqmiao@usst.edu.cn} ; Shuang Zhou^b ; ^{shuangzhou@tongji.edu.cn}
• 关键词：Bi(III) complex ; Thiosemicarbazones ; Anticancer activity ; in vivo ; Human lung cancer ; Drug
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：168
• 期：Complete
• 页码：18-26
• 全文大小：2102 K
• 卷排序：168

文摘

A Bi drug is derived from 2,6-pyridinedicarboxaldehyde bis(4N-methylthiosemicarbazone). The drug shows high anticancer activities against human lung cancer cells A549 and H460. No cytotoxicity is caused by the drug to normal human lung fibroblast (HLF) cell. The drug effectively inhibits A549 xenograft tumor growth on tumor-bearing mice. No harmful effect on mouse weight and liver is found after treatment with this drug.