ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation

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ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation

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作者：Yuko Atsumi¹ ; ² ; Yusuke Minakawa¹ ; ³ ; Masaya Ono⁴ ; Sachiko Dobashi¹ ; Keitaro Shinohe⁵ ; Akira Shinohara⁶ ; Shunichi Takeda⁷ ; Masatoshi Takagi⁸ ; Nobuhiko Takamatsu² ; Hitoshi Nakagama¹ ; Hirobumi Teraoka⁵ ; Ken-ichi Yoshioka¹ ; ^{kyoshiok@ncc.go.jp" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell Reports
出版年：2015
出版时间：29 December 2015
年：2015
卷：13
期：12
页码：2728-2740
全文大小：6042 K

文摘

•: H2AX is degraded via poly-ubiquitination mediated by HUWE1
•: H2AX is transiently stabilized upon DSB formation to efficiently form γH2AX foci
•: H2AX stabilization is mediated by ATM, SIRT6, and SNF2H

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