Disruptions of the genes involved in lysine biosynthesis, iron acquisition, and secondary metabolisms affect virulence and fitness in Metarhizium robertsii

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• 作者：Bruno Giuliano Garisto Donzelli^a ; ^{bdd1040@gmail.com} ; B. Gillian Turgeon^a ; Donna M. Gibson^b ; Stuart B. Krasnoff^b ; ^{stuart.krasnoff@ars.usda.gov}
• 关键词：AsMM ; Aspergillus minimal media ; ESIMS ; electrospray mass detection ; HRESIMS ; high-resolution electrospray ionisation mass spectrometry ; RBB ; Reciprocal Best Blast ; SM ; secondary metabolite ; BPS ; bathophenanthroline disulfonic acid ; SDS ; sodium dodecyl sulfate ; ONO ; L-ornithine N5-oxygenase ; AAR ; α-aminoadipate reductase
• 刊名：Fungal Genetics and Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：98
• 期：Complete
• 页码：23-34
• 全文大小：2360 K
• 卷排序：98

文摘

mrpptA deletion abolished of known M. robertsii PKS- and NRPS-derived compounds. ΔmrpptA strains were nearly avirulent against Drosophila suzukii. mraarA or mrsidA mutants had significantly decreased virulence. Residual Fe chelation in ΔmrsidA strains hints at novel non-hydroxamate siderophores.