ass=""h4"">Aims
The present study ev
alu
ated
a co
mp
ar
ative
and co
mbined hep
atoprotective effect of
atorv
ast
atin (AS)
and ferulic
acid (F)
ag
ainst high f
at diet (HFD) induced oxid
ative stress in ter
ms of hyperlipide
mi
a,
anti-oxid
ative st
atus, lipid peroxid
ation
and infl
ammation.
ass=""h4"">Main methods
Male Swiss albino mice were given a diet containing high fat (H) (23.9 % wt/wt), supplemented with AS (10 mg/kg) or F (100 mg/kg) and both (10 and 100 mg/kg) for 8 weeks. The control mice (C) were fed with normal diet.
ass=""h4"">Key findings
The H mice exhibited increased body weight; hyperlipidemia; serum level of tumor necrosis factor alpha (TNF-¦Á), interleukin-6 (IL-6); hepatic lipid profile; lipid accumulation; reactive oxygen species (ROS) of hepatocytes, lipid peroxidation and liver antioxidant capacity was decreased. Immunofluorescent and Western blot assay revealed activation of nuclear factor kappa B (NF-¦ÊB) signaling pathway. The addition of F or AS and both in the diet significantly counteracted HFD induced body weight gain; hyperlipidemia; TNF-¦Á, IL-6; hepatic lipid profile; fatty infiltration; NF-¦ÊB signaling pathway; ROS; lipid peroxidation and moreover elevated levels of hepatic antioxidant enzymes activity were observed.
ass=""h4"">Significance
Simultaneous treatment with AS, F and their combination protected against HFD induced weight gain and oxidative stress. The protection may be attributed to the hypolipidemic and free radical scavenging activity of AS or F and their combination. This study illustrates that AS and F have relatively similar hypolipidemic, antioxidative, anti-inflammatory actions and the AS + F combination along with HFD has shown outstanding effects as compared to other treated groups.
