The spliceosome: a novel multi-faceted target for therapy

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• 作者：Jamal Tazi ; Sé ; bastien Durand and Philippe Jeanteur
• 刊名：Trends in Biochemical Sciences
• 出版年：2005
• 出版时间：2005
• 年：2005
• 卷：30
• 期：8
• 页码：469-478
• 全文大小：1628 K

文摘

The spliceosome is a dynamic and flexible ribonucleoprotein enzyme that removes intronic sequences in a regulated manner. Spliceosome action enables one stretch of genomic DNA sequence to yield several mRNAs that encode different proteins. It depends on a flexible mechanism for selecting splice sites, which calls for regulatory sequences (splicing enhancers or silencers) recognized by cognate trans-acting protein factors and constitutive ribonucleoprotein devices to build up the catalytic core. The identification of both types of elements now offers a comprehensive insight into how the spliceosome is adapted to carry out the removal of different introns and suggests novel therapeutic targets to, ultimately, restore a physiological pattern of alternatively spliced variants in a large repertoire of pathologies.