Genetic correlation in otosclerosis
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文摘
Purpose: The aim of this study was to determine the relationship of HLAtyping in patients with otosclerosis.

Materials and Methods: We used a prospective study in which HLA typing of 100 surgically confirmed otosclerosis patients were compared with age and sex matched normal individuals.

Results: HLA-A3, HLA-A9, HLA-A11, and HLA-1313 were found to be significantly high (P< .05, .01, and.01, respectively). HLA-A9 and HLA-A11 were found to be higher (P< .01) in patients with a positive family history, indicating genetic heterogenicity.

Conclusions: Higher values of HLA-A9, HLA-11, and HLA-1313 in patients with otosclerosis compared with normal individuals strongly suggests a genetic, HLA-related component.

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