Purpose: The aim of this study was to determine the relationship of HLAtyping in patients with otosclerosis.
Materials and Methods: We used a prospective study in which HLA typing of 100 surgically confirmed otosclerosis patients were compared with age and sex matched normal individuals.
Results: HLA-A3, HLA-A9, HLA-A11, and HLA-1313 were found to be significantly high (P< .05, .01, and.01, respectively). HLA-A9 and HLA-A11 were found to be higher (P< .01) in patients with a positive family history, indicating genetic heterogenicity.
Conclusions: Higher values of HLA-A9, HLA-11, and HLA-1313 in patients with otosclerosis compared with normal individuals strongly suggests a genetic, HLA-related component.