Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia

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Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia

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作者：Marco Onorati¹ ; ¹⁴ ; Zhen Li¹ ; ¹⁴ ; Fuchen Liu¹ ; ¹⁴ ; André ; M.M. Sousa¹ ; ¹⁴ ; Naoki Nakagawa² ; Mingfeng Li¹ ; Maria Teresa Dell&rsquo ; Anno³ ; Forrest O. Gulden¹ ; Sirisha Pochareddy¹ ; Andrew T.N. Tebbenkamp¹ ; Wenqi Han¹ ; Mihovil Pletikos¹ ; Tianliuyun Gao¹ ; Ying Zhu¹ ; Candace Bichsel¹ ; Luis Varela⁴ ; Klara Szigeti-Buck⁴ ; Steven Lisgo⁵ ; Yalan Zhang⁶ ; Anze Testen² ; Xiao-Bing Gao⁴ ; Jernej Mlakar⁷ ; Mara Popovic⁷ ; Marie Flamand⁸ ; Stephen M. Strittmatter³ ; Leonard K. Kaczmarek⁶ ; ⁹ ; E.S. Anton² ; Tamas L. Horvath¹ ; ⁴ ; ¹⁰ ; ¹¹ ; ^{tamas.horvath@yale.edu" class="auth_mail" title="E-mail the corresponding author} ; Brett D. Lindenbach¹² ; ^{brett.lindenbach@yale.edu" class="auth_mail" title="E-mail the corresponding author} ; Nenad Sestan¹ ; ³ ; ⁴ ; ¹³ ; ¹⁵ ; ^{nenad.sestan@yale.edu" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell Reports
出版年：2016
出版时间：6 September 2016
年：2016
卷：16
期：10
页码：2576-2592
全文大小：8183 K

文摘

•: Derivation of human neocortical and spinal cord neuroepithelial stem (NES) cells
•: Zika virus (ZIKV) infects NES cells and radial glia, impairing mitosis and survival
•: ZIKV induces mitochondrial sequestration of centrosomal phospho-TBK1
•: Nucleoside analogs inhibit ZIKV replication, protecting NES cells from cell death

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