SIRP/CD47 signaling in neurological disorders

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SIRP/CD47 signaling in neurological disorders

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作者：Haiyue Zhang^a ; ^c ; Fengwu Li^b ; Yuanyuan Yang^a ; ^c ; Jun Chen^a ; ^{chenj2@upmc.edu" class="auth_mail" title="E-mail the corresponding author} ; Xiaoming Hu^a ; ^b ; ^{hux2@upmc.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：A尾 ; amyloid 尾 ; AD ; Alzheimer壮s disease ; CNS ; central nervous system ; IgSF ; immunoglobulin superfamily ; ICH ; inintracerebral hemorrhage ; DAP12 ; DNAX activation protein 12 ; ITAM ; immunoreceptor tyrosine-based activation motif ; ITIM ; immunoreceptor tyrosine-based inhibition motif ; MAPK ; mitogen-activated protein kinase ; MMP ; matrix metalloproteinase ; MS ; multiple sclerosis ; NO ; nitric oxide ; ROS ; reactive oxygen species ; SCI ; spinal cord injury ; SHP1 ; SH2 domain-containing phosphatase-1 ; (SIRP) ; Si
刊名：Brain Research
出版年：2015
出版时间：14 October 2015
年：2015
卷：1623
期：Complete
页码：74-80
全文大小：641 K

文摘

•: SIRP and CD47 regulate microglial activation.
•: SIRP and CD47 mediate the interplay between microglia and other CNS cells.
•: CD47 and SIRP伪 are important in neuroinflammation in the CNS disorders.
•: CD47 and SIRP伪 may play janus roles in certain pathological events.
•: Modulating CD47/SIRP伪 may have different effects depending on disease progress.

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