• 作者：Adriana J. van Ballegooijen ; MSc^&lowast ; ; ^{hanne.van.ballegooijen@vu.nl" class="auth_mail} ; Bryan Kestenbaum ; MD ; MS^&dagger ; ; Michael C. Sachs ; PhD^&dagger ; ; Ian H. de Boer ; MD ; MS^&dagger ; ; David S. Siscovick ; MD ; MPH^&Dagger ; ; Andrew N. Hoofnagle ; MD ; PhD^§ ; ; Joachim H. Ix ; MD ; MS^鈥?/sup> ; Marjolein Visser ; PhD^&lowast ; ; Ingeborg A. Brouwer ; PhD^&lowast ;
• 关键词：incident hypertension ; parathyroid hormone ; prospective study ; vitamin D
• 刊名：Journal of the American College of Cardiology
• 出版年：1 April, 2014
• 年：2014
• 卷：63
• 期：12
• 页码：1214-1222
• 全文大小：650 K

Objectives

Background

Disturbances in vitamin D metabolism are plausibly related to hypertension.

Methods

MESA (Multi-Ethnic Study of Atherosclerosis) is a community-based, prospective cohort with baseline measurements obtained between 2000 and 2002. We studied 3,002 men and women free of prevalent cardiovascular disease and hypertension, age 45 to 84 years at baseline. Serum 25-hydroxyvitamin D and intact parathyroid hormone were measured from previously frozen baseline samples using liquid chromatography-mass spectroscopy and a 2-site immunoassay, respectively. We used a complementary log-log model with interval censoring to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for 25-hydroxyvitamin D and parathyroid hormone concentrations with incident hypertension through聽2010.

Results

During a median follow-up of 9.0 years, 41% of the cohort (n聽= 1,229) developed hypertension. Mean serum 25-hydroxyvitamin D was 26.3 卤 11.2 ng/ml and mean parathyroid hormone was 41.2 卤 17.3 pg/ml. Compared with 25-hydroxyvitamin D聽鈮?0 ng/ml, 25-hydroxyvitamin D聽<20 ng/ml was associated with a greater hypertension risk (HR: 1.28 [95% CI: 1.09 to 1.50]), although the association was attenuated and not statistically significant after聽adjusting for potential confounders (HR: 1.13 [95% CI: 0.96 to 1.33]). Compared with parathyroid hormone聽<33 pg/ml, parathyroid hormone聽鈮?5 pg/ml was associated with a significantly greater risk of hypertension (HR: 1.27 [95% CI: 1.01 to 1.59]) after adjusting for potential confounders.

Conclusions

Lower 25-hydroxyvitamin D concentrations were not associated with a greater risk of incident hypertension. Higher serum parathyroid hormone concentrations showed a significant, but statistically marginal, relationship to the development of hypertension. These findings will require further confirmation. (Multi-Ethnic Study of Atherosclerosis; )