Identification of a novel fusion transcript between human relaxin-1 (RLN1) and human relaxin-2 (RLN2) in prostate cancer

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Identification of a novel fusion transcript between human relaxin-1 (RLN1) and human relaxin-2 (RLN2) in prostate cancer

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作者：Gregor Tevz^a ; ¹ ; Sean McGrath^b ; Ryan Demeter^b ; Vincent Magrini^b ; Varinder Jeet^a ; Anja Rockstroh^a ; Stephen McPherson^a ; John Lai^a ; Nenad Bartonicek^d ; Jiyuan An^a ; Jyotsna Batra^a ; Marcel E. Dinger^d ; ^e ; Melanie L. Lehman^a ; ^c ; Elizabeth D. Williams^a ; Colleen C. Nelson^a ; ^c ; ^{colleen.nelson@qut.edu.au" class="auth_mail" title="E-mail the corresponding author}
关键词：Prostate cancer ; RLN1 ; RLN2 ; Fusion ; SMRT sequencing ; RNA-Seq
刊名：Molecular and Cellular Endocrinology
出版年：2016
出版时间：15 January 2016
年：2016
卷：420
期：Complete
页码：159-168
全文大小：1978 K

文摘

•: A novel RLN1-RLN2 fusion was observed in LNCaP cells and normal and prostate cancer tissues.
•: The fusion putatively encodes a RLN2 isoform with a deleted secretory signal peptide.
•: RLN1 is underrepresented in PCa cell lines.
•: Androgens inversely regulate RLN1 and the RLN1-RLN2 fusion transcript.

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