Somatostatin receptor subtype 4 activation is involved in anxiety and depression-like behavior in mouse models

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Somatostatin receptor subtype 4 activation is involved in anxiety and depression-like behavior in mouse models

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作者：Bá ; lint Scheich^a ; ^b ; ^g ; ^{scheich.balint@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Balá ; zs Gaszner^d ; ^g ; ^{balazs.b.gaszner@aok.pte.hu" class="auth_mail" title="E-mail the corresponding author} ; Viktó ; ria Kormos^a ; ^b ; ^g ; ^{viktoria.kormos@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Kristó ; f Lá ; szló ; ^e ; ^g ; ^{kristof.laszlo@aok.pte.hu" class="auth_mail" title="E-mail the corresponding author} ; Csaba Á ; dori^f ; ^{csaba.adori@ki.se" class="auth_mail" title="E-mail the corresponding author} ; É ; va Borbé ; ly^a ; ^b ; ^g ; ^{eva.borbely@aok.pte.hu" class="auth_mail" title="E-mail the corresponding author} ; Zsó ; fia Hajna^a ; ^b ; ^g ; ^{zsofia.hajna@aok.pte.hu" class="auth_mail" title="E-mail the corresponding author} ; Valé ; ria Té ; kus^a ; ^b ; ^g ; ^{valeria.tekus@aok.pte.hu" class="auth_mail" title="E-mail the corresponding author} ; Kata Bö ; lcskei^a ; ^b ; ^g ; ^{kata.bolcskei@aok.pte.hu" class="auth_mail" title="E-mail the corresponding author} ; Istvá ; n Á ; brahá ; m^b ; ^e ; ^g ; ^{istvan.abraham@aok.pte.hu" class="auth_mail" title="E-mail the corresponding author} ; Erika Pinté ; r^a ; ^b ; ^c ; ^g ; ^{erika.pinter@aok.pte.hu" class="auth_mail" title="E-mail the corresponding author} ; Já ; nos Szolcsá ; nyi^a ; ^b ; ^c ; ^g ; ^{janos.szolcsanyi@aok.pte.hu" class="auth_mail" title="E-mail the corresponding author} ; Zsuzsanna Helyes^a ; ^b ; ^c ; ^g ; ^h ; ^{zsuzsanna.helyes@aok.pte.hu" class="auth_mail" title="E-mail the corresponding author}
关键词：Depression ; Anxiety ; Neuropeptides ; Somatostatin ; sst4 receptor ; Fos immunohistochemistry
刊名：Neuropharmacology
出版年：2016
出版时间：February 2016
年：2016
卷：101
期：Complete
页码：204-215
全文大小：3279 K

文摘

•: Somatostatin receptor subtype 4 gene-deleted mice (Sstr4^−/−) show increased anxiety.
•: Sstr4^−/− mice show increased depression-like behavior in the FST.
•: The somatostatin receptor subtype 4 agonist J-2156 exerts anxiolytic effect.
•: J-2156 has anidepressant-like effect in the TST and increases the Fos response.
•: 30">Somatostatin receptor subtype 4 is highly expressed in the amygdala.