Differential effects of myelin basic protein-activated Th1 and Th2 cells on the local immune microenvironment of injured spinal cord

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Differential effects of myelin basic protein-activated Th1 and Th2 cells on the local immune microenvironment of injured spinal cord

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作者：Jian-Guo Hu^a ; ^b ; ¹ ; Ling-Ling Shi^a ; ^c ; ¹ ; Yue-Juan Chen^a ; ^b ; Xiu-Mei Xie^a ; ^b ; Nan Zhang^b ; An-You Zhu^a ; Zheng-Song Jiang^b ; ^c ; Yi-Fan Feng^a ; ^b ; Chen Zhang^b ; Jin Xi^b ; He-Zuo Lü ; ^a ; ^b ; ^c ; ^{lhz233003@163.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Spinal cord injury ; Passive immunization ; Myelin basic protein ; Immune microenvironment ; Locomotor recovery
刊名：Experimental Neurology
出版年：2016
出版时间：March 2016
年：2016
卷：277
期：Complete
页码：190-201
全文大小：2902 K

文摘

•: The effect of MBP-Th1 and -Th2 cell transfer on SCI is investigated.
•: MBP-Th1 transfer produces microenvironment dominated by Th1 and M1 cells.
•: MBP-Th2 transfer produces microenvironment dominated by Th2, Treg and M2 cells.
•: MBP-Th1 has detrimental effect on SCI while that of MBP-Th2 is beneficial.

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