Dietary alpha-ketoglutarate increases cold tolerance in Drosophila melanogaster and enhances protein pool and antioxidant defense in sex-specific manner

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Dietary alpha-ketoglutarate increases cold tolerance in Drosophila melanogaster and enhances protein pool and antioxidant defense in sex-specific manner

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作者：Maria M. Bayliak^a ; ^{bayliak@ukr.net" class="auth_mail" title="E-mail the corresponding author} ; Maria P. Lylyk^a ; Halyna V. Shmihel^a ; Oksana M. Sorochynska^a ; Oksana V. Manyukh^a ; Stefan G. Pierzynowski^b ; ^c ; Volodymyr I. Lushchak^a ; ^{lushchak@pu.if.ua" class="auth_mail" title="E-mail the corresponding author}
关键词：ABTS ; 2 ; 2&prime ; -azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt ; AKG ; alpha-ketoglutarate ; H-SH ; high molecular mass thiol groups ; KPi ; potassium phosphate buffer ; L-SH ; low molecular mass thiol groups ; ROS ; reactive oxygen species ; TAC ; total antioxidant capacity ; TCA ; trichloroacetic acid
刊名：Journal of Thermal Biology
出版年：2016
出版时间：August 2016
年：2016
卷：60
期：Complete
页码：1-11
全文大小：1458 K

文摘

•: Dietary alpha-ketoglutarate (AKG) increases cold tolerance in adult m>D. melanogasterm> flies.
•: AKG enhances locomotor capability in male flies.
•: AKG provides higher levels of total free amino acids and proline in female flies.
•: AKG enhances total antioxidant capacity in flies of both sexes.
•: AKG protects males and females from cold stress by partly different mechanisms.