Role of sphingomyelinase in mitochondrial ceramide accumulation during reperfusion

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Role of sphingomyelinase in mitochondrial ceramide accumulation during reperfusion

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作者：I. Ramí ; rez-Camacho^a ; ¹ ; R. Bautista-Pé ; rez^b ; ¹ ; F. Correa^a ; M. Buelna-Chontal^a ; N.G. Romá ; n-Anguiano^a ; M. Medel-Franco^a ; O.N. Medina-Campos^c ; J. Pedraza-Chaverri^c ; A. Cano-Martí ; nez^d ; C. Zazueta^a ; ^{azazuetam@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
关键词：D609 ; tricyclodecan-9-yl-xanthogenate ; nSMase ; neutral sphingomyelinase ; DP ; double product ; 4&prime ; 6-Diamidino-2-phenylindole ; DAPI ; 4-HNE ; 4-hydroxynonenal ; DNPH ; dinitrophenyl hydrazine ; mCB ; mono-chloro-bimane ; TMB ; 3 ; 3&prime ; 5 ; 5&prime ; -tetramethylbenzidine ; TPP ; tetraphenylphosphonium ; CCCP ; carbonyl cyanide m-chlorophenylhydrazone ; ANT ; adenine nucleotide translocator ; SERCA ; sarco/endoplasmic reticulum Ca2 ; +-ATPase ; RC ; respiratory control ; Δψm ; mitochondrial transmembrane electri
刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
出版年：2016
出版时间：October 2016
年：2016
卷：1862
期：10
页码：1955-1963
全文大小：700 K

文摘

•: Ceramide accumulation in mitochondria is associated with reperfusion damage.
•: Sphingomyelinase inhibitor D609, attenuates cardiac dysfunction and oxidative stress.
•: Ceramide content and nSMase activity in mitochondria are directly related.
•: 20">Ceramide accumulation in mitochondria deregulates their function during reperfusion.

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