RAM-589.555 a new Polymerase-1 inhibitor as innovative targeted-treatment for multiple sclerosis

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• 作者：A Achiron^a ; ^b ; R Zilkha-Falb^a ; ¹ ; R Mashiach^c ; M Gurevich^a ; ¹ ; ^{gurevich@sheba.health.gov.il}
• 关键词：AUC ; area under curve ; Dpi ; day post immunization ; EAE ; experimental autoimmune encephalomyelitis ; MOG ; myelin oligodendrocyte glycoprotein ; MS ; multiple sclerosis ; POL1 ; RNA Polymerase-1 ; POL2 ; RNA Polymerase-2 ; RR ; relapsing-remitting ; SPCs ; Splenocytes
• 刊名：Journal of Neuroimmunology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：302
• 期：Complete
• 页码：41-48
• 全文大小：873 K
• 卷排序：302

文摘

RAM-589.555 is a water soluble, permeable compound, that specifically inhibits POL1. RAM-589.555 induces apoptosis and suppresses lymphocytes proliferation and viability. Oral administration of RAM589.555 delays EAE onset and reduced disease severity.