Biscinchona alkaloid catalysed Henry reaction of isatins: Enantioselective synthesis of 3-hydroxy-3-(nitromethyl)indolin-2-ones

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• 作者：Parvathaneni Sai Prathima ; Keesara Srinivas ; Kodicherla Balaswamy ; Racha Arundhathi ; Gajjaia Narsimha Reddy ; Balasubramanian Sridhar ; Mandapati Mohan Rao ; ^{mandapati@iict.res.in} ; Pravin R. Likhar ; ^{plikhar@iict.res.in}
• 刊名：Tetrahedron: Asymmetry
• 出版年：2011
• 出版时间：31 December, 2011
• 年：2011
• 卷：22
• 期：24
• 页码：2099-2103
• 全文大小：429 K

文摘

The direct catalytic enantioselective Henry (nitroaldol) reaction of isatins with nitromethane has been developed in the presence of a biscinchona alkaloid as a chiral organocatalyst. The resulting Henry adducts bearing C3-quaternary stereocentres were obtained in high yields (up to 94 % ) with high enantioselectivities (up to 97 % ee).