Phosphine-free thiopseudourea-Pd(II) complex catalyzed Larock heteroannulation of 2-haloamines with internal alkynes

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• 作者：Keesara Srinivas ; Parvathaneni Saiprathima ; Kodicherla Balaswamy ; M ; apati Mohan Rao
• 关键词：Thiopseudourea ; Larock indolization ; Phosphine free ; Palladium
• 刊名：Journal of Organometallic Chemistry
• 出版年：2013
• 出版时间：1 October, 2013
• 年：2013
• 卷：741-742
• 期：Complete
• 页码：162-167
• 全文大小：501 K

文摘

We examined the Pd-catalyzed heteroannulation of 2-haloamines with internal alkynes under phosphine-free conditions. The thiopseudourea palladium(II) complex (5) found to be an efficient catalyst for the Pd induced heteroannulation. Achieved high turnover number for the heteroannulation reactions of internal alkynes with 2-iodoaniline. A variety of 2-bromoanilines and N-tosyl substituted 2-bromoanilines effectively reacted with different substituted internal alkynes to give the corresponding indoles in good to high yields (1:1 ratio of regioisomers).