Cu@SnS/SnO₂ nanoparticles as novel sorbent for dispersive micro solid phase extraction of atorvastatin in human plasma and urine samples by high-performance liquid chromatography with UV detection: Application of central composite design (CCD)

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• 作者：Mehdi Dastkhoon^a ; Mehrorang Ghaedi^a ; ^{m_ghaedi@mail.yu.ac.ir} ; ^{m_ghaedi@yahoo.com} ; Arash Asfaram^a ; Maryam Arabi^a ; Abbas Ostovan^b ; Alireza Goudarzi^c
• 关键词：Atorvastatin ; Central composite design ; Ultrasound assisted extraction ; HPLC&ndash ; UV ; Human plasma samples ; Plackett&ndash ; Burman design
• 刊名：Ultrasonics Sonochemistry
• 出版年：2017
• 出版时间：May 2017
• 年：2017
• 卷：36
• 期：Complete
• 页码：42-49
• 全文大小：1550 K
• 卷排序：36

文摘

Cu@SnS/SnO2 nanoparticles were synthesized as efficient solid phase. The first use of ultrasounds in the extraction of atorvastatin. The sorbent has highly binding capacity and extraction, desorption processes are convenient and rapid. Optimize conditions were obtained by experimental design methodology to ensure reduce error and experimental. Proposed method has lower detection limit compared previous works.