Efficacy and safety of an adjunctive mGlu2 receptor positive allosteric modulator to a SSRI/SNRI in anxious depression

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Efficacy and safety of an adjunctive mGlu2 receptor positive allosteric modulator to a SSRI/SNRI in anxious depression

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作者：Justine M. Kent^a ; ^{jkent@its.jnj.com" class="auth_mail" title="E-mail the corresponding author} ; Ella Daly^a ; Iva Kezic^b ; Rosanne Lane^a ; Pilar Lim^a ; Heidi De Smedt^c ; Peter De Boer^c ; Luc Van Nueten^c ; Wayne C. Drevets^a ; Marc Ceusters^c
关键词：MDD ; major depressive disorder ; SSRI ; selective serotonin reuptake inhibitor ; SNRI ; serotonin-norepinephrine reuptake inhibitor ; PAM ; positive allosteric modulator ; mGluR2 ; metabotropic glutamate 2 receptor ; STAR*D ; Sequenced Treatment Alternatives to Relieve Depression ; DSM-IV ; Diagnostic and Statistical Manual of Mental Disorders ; Fourth Edition ; HDRS ; Hamilton Depression Rating Scale ; IDS ; Inventory of Depressive Symptomatology ; SPCD ; sequential parallel comparison design ; HAM ; Hamilton Anxie
刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
出版年：2016
出版时间：3 June 2016
年：2016
卷：67
期：Complete
页码：66-73
全文大小：863 K

文摘

•: Data do not suggest efficacy for JNJ-40411813 as an adjunctive treatment for patients with MDD with significant anxious symptoms.
•: Overall, JNJ-40411813 was well-tolerated in the dose range studied.

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