The Staudinger/aza-Wittig Grignard reaction cascade is a concise synthetic method for the synthesis of biologically active 1-C-alkyl iminoalditol glycomimetics.

A concise synthetic approach to biologically active 1-C-alkyl iminoalditol glycomimetics: The Staudinger/aza-Wittig Grignard reaction cascade.

The stereoselective control of C-1 alkyl substitution can be controlled by the choice of protecting groups at the sugar substrate as well as the nature of the nucleophilic Grignard reagent in the Staudinger/aza-Wittig Grignard reaction cascade.

Compounds exhibit selective b-glucosidase inhibition.