Endogenous modulation of TrkB signaling by treadmill exercise after peripheral nerve injury

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• 作者：Ariadna Arbat-Plana ; Stefano Cobianchi ; Mireia Herrando-Grabulosa ; Xavier Navarro ; Esther Udina ; ^{esther.udina@uab.cat}
• 关键词：7 ; 8-DHF ; 7 ; 8-dihydroxyflavone ; ANOVA ; analysis of variance ; BDNF ; brain-derived neurotrophic factor ; EDTA ; ethylenediaminetetraacetic acid ; GM ; gastrocnemius medialis ; KCC2 ; K+&ndash ; Cl&minus ; cotransporter 2 ; NT-3 ; neurotrophin-3 ; PBS ; phosphate buffered saline ; PNN ; perineuronal nets ; Syn ; synaptophysin ; TA ; tibialis anterior ; TrkB ; tropomyosin-related kinase ; TR ; treadmill running ; ANA-12 ; N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-benzo[b]thiophene-2-carboxamide
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：6 January 2017
• 年：2017
• 卷：340
• 期：Complete
• 页码：188-200
• 全文大小：3263 K
• 卷排序：340

文摘

TrkB agonist is not able to mimic all the positive effects of treadmill exercise following peripheral nerve injury. Over activation of TrkB could have harmful effects in VGlut1 synapses. TrkB inactivation blocks the maintenances of synapses by treadmill exercise after axotomy. Physical exercise is better than pharmacological modulation of TrkB to attenuate the changes on axotomized motoneurons.